Reaction Mechanism in the Human Plasma Lipid Transfer Protein
نویسندگان
چکیده
منابع مشابه
Diet-induced alteration in the activity of plasma lipid transfer protein in normolipidemic human subjects.
Studies were performed to investigate the effect of diets rich in oleic or linoleic acids on the activity of plasma cholesteryl ester transfer protein (CETP) in normolipidemic subjects. Previous to the test diets, all subjects consumed a baseline diet rich in saturated fatty acids ("sat-diet") for 17 days. The test diets, rich in either monounsaturated fatty acids ("mono-diet") or rich in polyu...
متن کاملPlasma lipid transfer proteins
The composition of the plasma lipoproteins is continuously modified during their intravascular metabolism, as a result of a dynamic exchange and net transfer of lipids between particles or between particles and cells. Specialized proteins, the plasma lipid transfer proteins, facilitate the transfer and exchange of phospholipids, cholesteryl esters, and triglycerides between the lipoproteins. Al...
متن کاملPlasma lipid transfer proteins.
The plasma lipid transfer proteins mediate the transfer and exchange of phospholipids and neutral lipids between the plasma lipoproteins. The cholesteryl ester transfer protein (CETP) and the phospholipid transfer protein (PLTP) are members of the lipid transfer/lipopolysaccharide binding gene family. The CETP contains binding sites for cholesteryl ester and triglycerides and probably acts by a...
متن کاملBinding of plasma-derived lipid transfer protein to lipoprotein substrates. The role of binding in the lipid transfer process.
Plasma-derived lipid transfer protein (LTP) facilitates the transfer of cholesteryl ester and triglyceride between all lipoproteins. Kinetic models of the transfer event have suggested that transfer is facilitated through the physical interaction (binding) of LTP with its lipoprotein substrate. Such binding has been observed previously between LTP and high density lipoprotein (HDL), but not bet...
متن کاملDetermination of lipid transfer inhibitor protein activity in human lipoprotein-deficient plasma.
Lipid transfer protein (LTP) activity is modulated by a distinct plasma protein termed lipid transfer inhibitor protein (LTIP). The objective of this study was to establish an assay for LTIP that could be used to quantify its activity in lipoprotein-deficient plasma. A straightforward heating protocol (56 degrees C for 60 minutes) was found to inactivate more than 90% of LTIP activity. The resp...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1990
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.18.9-10_869